田原副教授

硕士生导师

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学科：化学. 药学. 生物学

所在单位：生命科学与工程学院

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论文成果

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PUBLICATIONS

(‡ contributed equally; * corresponding author)

30. Peng L., Li Q., Li Z.,Tian Y.*,Zhou S. B.* "A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain"Angew. Chem. Int. Ed.,2025, e20279.

29. Jiang Z., Huang J., He Y., Peng L., Li Q.,Tian Y.*,Zhou S. B.* "A Tailor-Made Biaryl-Stapled Peptide Nanoprodrug with Esterase-Triggered Dual Immunomodulation for Amplified Cancer Therapy"Nano Lett.,2025, 25, 44, 16020-16029.

28. He M., Jiang Y.*, Yang Y., Gong K., Jiang X.,Tian Y."MSCMamba: Prediction of Antimicrobial Peptide Activity Values by Fusing Multiscale Convolution with Mamba Module"J. Phys. Chem. B,2025, 129, 7, 1956–1965.

27. Wang S., Wu J.*,Tian Y.*, Zhou S. B.* "Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities."Sci. China Mat.,2024,In press. (IF: 8.100) (co-corresponding author)

26. Song Y., Wang R., Pan Y.,Tian Y.*, Zhou S. B.* "An integrated quorum quenching biocatalytic nanoplatform for synergistic chemo-photothermal eradication of P. aeruginosa biofilm infections."Acta. Biomater.,2023,171,532-542. (IF: 10.633) (co-corresponding author)

25.Tian Y.‡*, Lu L.‡* "Recent advances in self-assembling peptide matrices as functional coatings for implantable devices."Front. Chem.,2022,10,1040499. (IF: 5.545, Invited Review) (contributed equally; co-corresponding author)

24. Fang D., Wang R., Yu X.,Tian Y.*"Construction of cyclic cell-penetrating peptides for enhanced penetration of biological barriers."J. Vis. Exp.,2022,187,e64293. (IF: 1.424, Invited Protocol)

23. Xiao Y., Zhang L., Shi M., Tang R., Jiang Z., Song Y.,Tian Y.*, Zhou S. B.* "pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy."Nano Res.,2022,15,8315-8325. (IF: 10.269) (co-corresponding author)

22. Shi M., Jiang Z., Xiao Y., Song Y., Tang R., Zhang L., Huang J.,Tian, Y.*, Zhou S. B.* "Stapling of short cell-penetrating peptides for enhanced tumor cell-and-tissue dual-penetration."Chem. Commun.,2022,58, 2299-2302. (IF: 6.065) (co-corresponding author)

21. Tang R., Song Y., Shi M., Jiang Z., Zhang L., Xiao Y.,Tian Y.*, Zhou S. B., "Rational design of a dual-targeting natural toxin-like bicyclic peptide for selective bioenergetic blockage in cancer cells."Bioconjugate Chem.,2021,32,2173–2183. (IF: 6.069)

20.Tian Y., Zhou S. B.*, "Advances in cell penetrating peptides and their functionalization of polymeric nanoplatforms for drug delivery"WIREs Nanomed. Nanobi.,2021,13, e1668. (IF: 9.423)

19. Ming Y., Xiao Y.,Tian Y.*, Zhou S. B.*, “Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.”Macromol. Biosci.,2019,19, 1800364. (IF: 5.859) (co-corresponding author)

18. Yuan F.‡,Tian Y.‡, Qin W. R.‡, Li J. X., Yang D., Zhao B. C., Yin F.*, Li Z. G.*, “Evaluation of Topologically Distinct Constrained Antimicrobial Peptides with Broad-Spectrum Antimicrobial Activity”Org. Biomol. Chem.,2018,16, 5764-5770. (IF: 3.890) (contributed equally)

17. Qin. X, Zhao. H, Jiang Y. H., Yin F.,Tian Y., Xie M. S., Ye X. Y., Xu N. H., Li Z. G.*, "Development of a potent peptide inhibitor of estrogen receptor α"Chin. Chem. Lett.,2018,29, 1160-1162. (IF: 8.455)

16. Shi, X. D., Zhao, R. T., Jiang, Y. X., Zhao, H.,Tian, Y., Jiang, Y. H., Li, J. X., Qin, W. R., Yin, F.*, Li, Z. G.*,“Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation”Chem. Sci.,2018,9, 3227-3232. (IF: 9.969)

15. Shi, X. D.‡, Jiang, Y. X.‡, Yang, D.‡, Zhao, H.,Tian, Y.*, Li, Z. G.*, “Reversibly Switching the Conformation of Short Peptide through In-Tether Chiral Sulfonium Auxiliary.”Chin. Chem. Lett.,2018,29, 485-488. (IF: 8.455) (co-corresponding author)

14.Tian, Y.‡, Zeng, X. Z.‡, Li, J. X.‡, Jiang, Y. H., Zhao, H., Wang, D. Y., Huang, X. H.*, Li, Z. G.*, “Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning.”Chem. Sci.,2017,8, 7576-7581. (IF: 9.969)

13.Tian, Y.‡, Jiang, Y. H.‡, Li, J. X., Wang, D. Y., Zhao, H., Li, Z. G.*, “Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: a Comparative Study.”ChemBioChem,2017,18, 2087-2093. (IF: 3.461) (Inside Back Cover)

12. Li, J. X., Hu, K., Chen, H. L., Wu, Y. J., Chen, L. J., Yin, F.*,Tian, Y.*, Li, Z. G.*, “In-tether chiral center modulates the proapoptotic activity of KLA peptide.”Chem. Commun.,2017,53, 10452-10455. (IF: 6.065) (co-corresponding author)

11. Zhao H.‡, Qin X.‡, Yang D.‡, Jiang Y. H., Zheng W. H., Wang D. Y.,Tian Y., Liu Q. S., Xu N. H.* and Li Z. G.*, “The development of activatable lytic peptides for targeting triple negative breast cancer”Cell Death Discov.,2017,3, 17037. (IF: 7.109)

10. Jiang, Y. H., Zhao, H.,Tian, Y., Li, Z. G.*, “Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems.”Synlett,2017,28, 1897-1900. (IF: 2.170)

9.Tian, Y.‡, Yang, D.‡, Ye, X. Y.*, Li, Z. G.*, “Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.”Chem. Rec.,2017,17, 874-885. (IF: 6.935)

8. Zhao, H., Jiang, Y. H.,Tian, Y., Qin, X., Li, Z. G.*, “Improving Cell Penetration of Helical Peptides Stabilized by N-Terminal Crosslinked Aspartic Acids.”Org. Biomol. Chem.,2017,15, 459-464. (IF: 3.890)

7. Li, J. X.,Tian, Y., Wang, D. Y., Li, Z. G.*, “An In-Tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-Capped Peptides.”Bioorg. Med. Chem.,2016,25, 1756-1761. (IF: 3.461)

6. Zhang, Q. Z., Jiang, F., Zhao, B. C., Lin, H. C.,Tian, Y., Xie, M. S., Bai, G. Y., Gilbert, A. M., Gietz, G. H., Liras, S., Mathiowetz, A. A., Price, D. A., Song, K., Tu, M. H., Wu, Y. J., Wang, T.*, Flanagan. M. E.*, Wu, Y. D.*, Li, Z. G.*, “Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.”Sci. Rep.,2016,6, 38573. (IF: 4.996)

5. Zhao, H.‡, Liu, Q. S.‡, Geng, H.‡,Tian, Y., Cheng, M., Jiang, Y. H., Xie, M. S., Niu, X. G., Jiang, F., Zhang, Y. O., Lao, Y. Z., Wu, Y. D.*, Xu., N. H.*, Li, Z. G.*, “Cross-Linked Aspartic Acids as Helix-Nucleating Templates.”Angew. Chem. Int. Ed.,2016,128, 12088-12093. (IF: 16.823)

4.Tian, Y.‡, Wang, D. Y.‡, Li, J. X., Shi, C., Zhao, H., Li, Z. G.*, “A Proline-Derived Transannular N-Cap for Nucleation of Short α-Helical Peptides.”Chem. Commun.,2016,52, 9275-9278. (IF: 6.065)

3.Tian, Y., Li, J. X., Zhao, H., Zeng, X. Z., Liu, Q. S., Wang, D. Y., Niu, X. G., Huang, X. H., Xu, N. H.*, Li, Z. G.*, “Stapling of Unprotected Helical Peptides via Photo-Induced Intramolecular Thiol-Yne Hydrothiolation.”Chem. Sci.,2016,7, 3325-3330. (IF: 9.969)

2. Liu, Q. S.‡, Zhao, H.‡, Jiang, Y. H., Wu, M.,Tian, Y., Wang, D. P., Lao, Y. Z., Xu, N. H., Li, Z. G.*, “Development of a Lytic Peptide Derived from BH3-Only Proteins.”Cell Death Discov.,2016,2, 16008. (IF: 7.109)

1. Zhang, Q. Z.,Tian, Y., Lao, Y. Z., Li, Z. G.*, “Peptides-Staple Method Development and Its Application in Cancer Therapy.”Curr. Med. Chem.,2014,21, 2438-2452. (IF: 4.740)